★★★Betulinic Acid Concentrate: Made with White Birch – Betula Pubescens ( embryonic internal bark of roots) and Sweet Almond – Prunus amygdalus ( embryonic husk and embryonic fruit).

Is a broad-spectrum embryonic extract with many anticancer biological activities and is used as an oncophytoembryonic therapy to treat, inhibit and/or prevent malignant tumors of the colon, small intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma. The concentrate uses an herbal extract of White Birch embryonic internal and external bark with Sweet Almond embryonic husk and embryonic fruits rich in betulinic acid and other synergistic phytochemical composition. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis, inhibiting vascular endothelial growth factors and thus causing an antiangiogenic effect.

★★Sweet Almond – Prunus amygdalus (husk and fruit) is a stone fruit related to cherry, plum, and peach, containing Betulinic acid, which showed antiproliferative activity toward MCF-7 cells (GI50 = 0.27 μM), higher than the anticancer drug 5-fluorouracil; also contains Morin (3, 5, 7, 2’, 4’-pentahydroxyflavone) P-glycoprotein (P-gp) with ATPase activity inhibitors; exhibits potential cytotoxicity; as neuroprotective of the aging brain. Morin also has pleiotropic effects on kinase signaling pathways, including inhibition of activation of protein kinase B by mutagens (but not extracellular-regulated kinases 1/2) and activation of the stress pathway kinases, Jun N-terminal kinase and p38 kinase. p38 kinase activation is functionally important since inhibition of its activation by the specific inhibitor SB202190 partially prevented cell cycle arrest by morin.

Interactions: Sweet Almond – P. amygdalus (husk and fruit): Consumption may cause drowsiness with interaction of benzodiazepines, barbiturates, and narcotics.

Oligo-elements: Cu, Fe, I, K, Mg, Mn, P, Zn.

Vitamins and Minerals: B-1, B-2, B-3, B-5, B-6, B-9 Folic acid, C, Calcium, E, B-9 Folic acid.

Prominent Phytochemical Constituents: Amadin (for antigenicity), Arginine, Aspartic-Acid, Benzaldehyde, Beta-Carotene, Betulinic acids, Corosolic acid, Daucosterol, Kaempferol, Morin (2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one), Naringenin 7-O-b-D-glucopyranoside, Oleic-Acid, larger amount of Olein than Olive but devoid of chlorophyll, Prunasin, Quercetin, Quercitrin, Resveratrol, Rutinoside, Serine, Sphingolipids Stearic-Acid, The sterols (3β,22E)-stigmasta-5,22-dien-3-ol (stigmasterol) and (3β)-stigmast-5-en-3-ol (β-sitosterol), Tannin, Taxi Olin, Threonine, Tryptophan, Tyrosine, Uridine, Ursolic acid, Valine, Vanillic Acid. A new unusual sesquiterpene lactone, named amygdalactone, was isolated from the hulls of almond (Prunus amygdalus). The cytotoxic activity of amygdalactone produces a new unusual kauranoid diterpene glycoside, named amygdaloside. The phenols from the embryonic husks showed a higher antioxidant capacity of 58 %. Another proteid body, which is likewise soluble in water, is present in the almonds. It was named conglutin, by Ritthausen, while Comaille denominated it amandin.

★★Sweet Almond – Prunus amygdalus (husk) phytochemicals: The lignocellulosic residues from the husks are used to optimize the yield of polyphenolic antioxidant compounds. The antioxidant power of these extracts was evaluated by the ability to scavenge 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical, the superoxide anion radical (O2), the hydroxyl radical (OH), or the peroxyl radical (ROO). The total phenolics content from husks showed potent antioxidant capacity of 58%, reducing ROS species.

Peroxisome proliferator-activated receptor-gamma (PPARγ), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents. PPARγ was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later on, it became evident that it is also involved in cell differentiation, apoptosis and angiogenesis, biological processes which are hallmarks of cancer. It is now established that PPARγ ligands can induce cell differentiation and yield early antineoplastic effects in several tumor types. Moreover, several bioactive natural products with cancer protecting potential are shown to operate through activation of PPARγ. Overall, PPARγ appears to be a prevalent target ally to cancer chemopreventive agents. Thus research in this area is of great relevance.

Triturated with water, sweet almonds produce a white mixture called emulsion or milk of almonds, which possesses a very remarkable analogy with animal milk; it contains a. great quantity of oil, kept in suspension in water by the presence of sugar, gum, and albumen, and is used as a demulcent and as a vehicle for other medicines. It is frequently employed in cough, diseases attended with intestinal irritation, and for mitigating the acrimony of the urine in calculus affections.

A proteid is a protein and one of a class of principles which are amorphous and nitrogenous. As a rule, proteids also contain such constituents as a small amount of sulphur, an albuminoid as blood fibrin, casein of milk, etc. Proteids are present in nearly all animal fluids and make up the greater part of the organs and tissues of animals. Proteids are also important constituents of the tissues of vegetables. The word proteid is derived from the Greek word for “first.”

The words proteid and protein are almost similar. However both are defined as organic compounds which are made up of such elements as carbon, hydrogen, oxygen and nitrogen and also traces of other elements. They are essential to life in food and as a part of every living cell. Proteinaceous and proteinous are the adjective form of the word protein.

Many, perhaps all, colorless plants can make the most complex foods (proteids), provided simpler foods and necessary salts are supplied. Only green plants, however, and of these only the green parts, can make carbohydrate foods, like sugars, starch and the like, out of carbon dioxide and water. When these foods have been formed in sufficient amount, the green plants can also produce proteids. Most plants make more food than they require. Reserve food is stored, usually in solid form, in special tissues. Nuts, peas, beans, and lentils are far richer than any kind of flesh in these elements, and they have this enormous advantage, that the proteids are pure, and therefore contain all the energy originally stored up in them during their organization. In the animal body these proteids which the animal has absorbed from the vegetable kingdom during its life, are constantly passing down to disorganization, during which descent the energy originally stored in them is released. Consequently what has been used already by one animal cannot be utilized by another. The proteids are estimated in some of this analysis by the amount of nitrogen contained therein, but in flesh-meat there are many products of tissue-change such as urea, uric acid, and creatine all of which contain nitrogen and are therefore estimated as proteids, though they have no food value whatever.

Nor is this all the evil; for this tissue-change is necessarily accompanied by the formation of various poisons, which are always to be found in flesh of any kind. In many cases the virulence of these poisons is high. In fact, any nourishment to be gained from the eating of the dead flesh is obtainable only because during its life the animal consumed vegetable matter. Thus this nourishment is insufficient since the animal has already used up half, and along with the fish come various undesirable substances, and even some active poisons, which are, of course, distinctly deleterious.

Betulinic acid, which is found in several species of plants, has shown pro-PPARγ activities in cancer and downregulation of cyclooxygenase-2 and cyclin D1. The human PPARγ gene consists of six coding exons located at chromosome 3p25.2 and extends approximately over100kb of genomic DNA. Apoptosis is believed to be a fundamental molecular mechanism through which PPARγ activators exert their action against cells which undergo malignant transformation. Moreover, apart from their direct inhibitory effects on cancerous transformed cells, PPARγ can also inhibit angiogenesis which is a prerequisite for tumor formation and growth. It is suggested that the antiangiogenic activity of PPARγ can be accomplished either by blocking the production the angiogenic ELR+CXC chemokines by cancer transformed cells or by inducing expression of the thrombospondin-1 receptor CD36 in endothelial cells. In addition, latest exciting data, which showed that PPARγ agonists were able to inhibit the canonical WNT signaling in human breast cancer, colonic epithelium cancer, lung cancer, pancreatic cancer, raises hopes that such agents can possibly block cancer initiation at a stem cell level.

(References: V. G. Keshamouni, D. A. Arenberg, R. C. Reddy, M. J. Newstead, S. Anthwal, et al., "PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer," Neoplasia, vol. 7, no. 3, pp. 294-301, 2005.

H. Huang, S. C. Campbell, D. F. Bedford, T. Nelius, D. Veliceasa, et al., "Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510," Mol Cancer Res, vol. 2, no. 10, pp. 541-550, 2004.

M. F. McCarty, J. Barroso-Aranda, F. Contreras "PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation," Med Hypotheses, vol. 70, no. 2, pp. 419-423, 2008.)