★★★White Birch – Betula pubescens (bark of roots internal and external): This is a Polycrest Apotosis Agent--a chemotherapeutic agent without toxicity. The embryonic internal White Bark of Root mix with the husk and embryonic fruit of the Sweet Almond Tree is where betulinic acid is most concentrated. Stimulate the central nervous and neuro humoral (they increase the activity of estrogens) systems of organism, improve metabolism including activation of metabolism in cerebral tissue, restore activity of stagnant systems, regulate the activity of the cardiovascular and respiratory systems, stimulate the homogeny (increase the level of leukocytes), act as the over-all strengthening means, increase the resistibility to infectious diseases, possess antipyretic properties during the internal and local application, strengthen the cytostatic activity of antitumorigenic preparations, detains increase of tumors, causes their gradual regression and slows down the development of metastases, i.e. they themselves possess cytostatic action. In this case the health of patients considerably improves, their fitness for work is restored, and general tone rises.

Hematology – Oncology: Melanoma. PPARγ agonist, TNF – Tumor Necrosis Factor and NIGF – Nerve Growth Factor, p53 oncogene, anti-angiogenic activity of BetA occurs through a modulation of mitochondrial function rather than APN activity in endothelial cells, Adaptosis. Apoptotic, Topoisomerases Inhibitor. Protein Kinase Inhibitors by amphiphilic triterpenoids; Nitric Oxide Inhibitor, Prostaglandin-Inhibitor Prostate, Antimetastatic. Inhibit the growth of different kinds of tumors, Cancers of the brain medulloblastoma and glioblastoma cells, breast, colon, esophagus, lymphoma, stomach, non-small cell lung carcinoma, selective inhibitor of human melanoma and other skin cancers. Has exhibited up to 92% inhibition of prostate tumor growth.

Immunology Infectious Diseases: B. pubescens is high in betulinic acid, a phytochemical isolated from birch trees, which demonstrates significant immune-supporting actions and has an affinity for tissues that have a low pH. Specifically,splenic lymphocytes translate and activity of NK cell, antitumor, Increases WBC’s and Interferon production. BA is adaptogenic. Typically, unhealthy joint tissue will maintain a lower pH, attracting this potent phytochemical to that area; supporting healthy immune function where it is needed most.

Oligo-elements: Co, Cu Fe, K, Mg, Mn, Ni, Zn.

Vitamins and Minerals: A, B-1, B-2, Calcium, E, Inositol.

Prominent Phytochemical Constituents: Pentacyclic triterpenes Betulin, Betulinic acid, Betulin 3-caffeate, B-Sitosterol, Catechin-Gallic acid, Chlorogenic Acid, Diarylheptanoid glucoside Platyphylloside, Kaempferol, Moronic acid, lignan glycosides lyoniside, nudiposide, (−)-isolariciresinol, 3 a-O-B-D-xylopyranoside. A new Oleanene-type triterpene, named betuloleanolic acid acetate and fernane-type triterpenes, namely betufernanediol A and betufernanediol B (isomers) have been isolated from the stem bark of embryonic Birch.

Biological Activities: Birch bark contains a variety of apoptosis-inducing and anti-inflammatory substances; aphidifuge; cytotoxic; hypolipemic; anti-actinic keratoses; antioxidant; antibacterial; anticarcinomic; antimutagenic; anti-inflammatory; antitumor; apoptotic. Dosage: 50 to 100 drops, 3 times a day.

Betulin (lup-20(29)-ene-3β,28-diol) is an abundant naturally-occurring triterpene. It is commonly isolated from the bark of embryonic bark about 30% of the White birch where it is more concentrated and smaller amount about 10% is found in the buds of Silver birch trees. It can be converted to betulinic acid, which is biologically more active than betulin itself.

Betulinic acid has generated considerable interest as an anti-cancer drug. The compound has exhibited up to 96% inhibition of prostate tumor growth acid arrested mitosis and induced apoptosis. Betulinic acid is a new cytotoxic agent fighting malignant brain-tumor cells, medulloblastoma and glioblastoma cells and neuroectodermal tumor cells, including neuroblastoma, medulloblastoma, glioblastoma and Ewing's sarcoma cells. Betulinic acid was reported as a selective inhibitor of human melanoma.

Examinations conducted in the Russian Institute of Pharmacology showed that the complex of substances forming part of white part of birch bark possesses high antimutagenic activity, capable of lowering the number of mutations in the chromosomes and the genes, the frequency of the appearance of hereditary changes in the organism. The antimutagenic action of the substances of white part of birch bark is connected with their capability for the suppression of free-radical oxidation, and in the ability of white part of birch bark to induce the production of interferon’s, which, as it’s known, positively influence the processes of reparation of DNA. The substances, contained in white part of birch bark contribute to the decrease of hypoxia and to increase of the stability of organism to the oxygen deficiency, being antihypoxant correcting the metabolism of cells.

The antioxidant activity of betulin is connected with its direct effect on the ferments of the antioxidant protection, whose basic functional role consists of the decomposition of organic peroxides, including all peroxides of lipids, which play paramount role in the disturbance of the normal structure of biological membranes. Substances forming betulin possess a high gepatoprotektornoy and detoxifying activity, inducing the ferments of the rendering safe system of the liver, it normalizes bile secretion, reduces cholesterol level in the blood.

(References: This study for Prostate cancer was funded in part by Marc Pharmaceuticals. NY July 24,2006. Dr. Saxena, scientists have been aware of the anti-cancer potential of the birch bark compound betulinol, and its derivative, betulonic acid, since the 1970s.

Co-authors included Dr. Arkadiy Bomshteyn, Dr. Meirong Hao, Ms. Eileen Kisilis, Dr. Meena Katdare and Dr. Ozgur Oktem — all of Weill Medical College of Cornell University; and Dr. Lei Zhu, of Memorial Sloan-Kettering Cancer Institute, New York City.)

The Journal of Immunology (2003, 171: 3278-3286) reported that Betulinic acid (BA), a pentacyclic triterpene isolated from the bark of the White Birch tree, has been shown to be a selective inducer of apoptosis in cancerous tumor cells. It also exhibits anti-inflammatory and immunomodulatory properties.

A group of NIEHS-supported researchers at the Texas A&M Health Sciences Center reports that betulinic acid might be an effective treatment for prostate cancer. In a series of experiments using prostate cancer cell cultures and an animal model of prostate cancer, betulinic acid treatment decreased the growth of the cancer cells. Further work elucidated the mechanism of betulinic acid’s effect. The compound induced proteosome-dependent degradation of the specificity protein transcription factors Sp1, Sp3, and Sp4 in the prostate cancer cells. These factors are over expressed in many tumor types.

These results indicate the anti-tumor effects of betulinic acid are associated with specific degradation of specificity protein transcription factors resulting in the inhibition of blood vessel formation and the activation of pro-apoptotic responses in tumors but not in non-target tissues exhibiting low specificity protein expression. Ongoing studies with betulinic acid are investigating tumor-type similarities and more potent formulations for possible new chemotherapeutic agents.

(References: Chintharlapalli S, Papineni S, Ramaiah SK, Safe S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res. 2007 Mar 15; 67(6):2816-23.)